2011-2012 Basic and Clinical Science Course, Section 9: by Ramana S. Moorthy MD

By Ramana S. Moorthy MD

Starts with an in-depth evaluate of immunemedicated eye sickness, summarizing easy immunologic options, ocular immune responses and precise issues in ocular immunology. Discusses the medical method of uveitis and stories noninfectious (autoimmune) and infectious sorts of uveitis, with an improved part on viral uveitis and new fabric on infectious and noninfectious scleritis. more desirable detection of infectious brokers by means of immunologic and genetic tools and new biologic therapeutics are distinctive. additionally covers endophthalmitis, masquerade syndromes, issues of uveitis and ocular points of AIDS. incorporates a variety of new colour pictures. significant revision 2011-2012

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Additional info for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)

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IL-4 can also induce macrophage granulomas in response to parasite-derived antigens. 2-3 Ocular Inflammatory Diseases Thought to Require a Major Contribution of Th1-Mediated DH Effec10r Mechanisms Site Disease Presumed Antigen Conjunctiva Contact hypersensitivity to contact lens solutions Giant papillary co njun ctivitis Phlycten ulosis Chronic allog raft rejection Marginal infiltrates of blepharitis Disciform keratitis after vira l infection Acute anterior uveitis Sarcoidosis-associated uveitis Intermediate uveitis Sympathetic op hthalmia Vogt-Koyanagi- Harada syndrome Birdshot retinochoroidopathy Acute thyroid orbitopathy Giant cell arteritis Thim erosa l or other chemicals Cornea and sclera Anterior uvea Retina and choroid Orbit Unknown Bacteria l anti gens Histocompatibility antigens Bacterial antigens Viral antigens Uveal autoantigens.

Differences in the primary and secondary immune response arc. especially in the processing and effector phases. offer partial explanation. During the processing phase of the primary response. 000) and then stimulate these cells from a completely resting and naive state. a sequence that requires days. The secondary processing response for T and B lymphocytes is shorter for at least 3 reasons: • Upon removal of antigen. T and B lymphocytes activated during the primary response may gradually return to a resting state.

5th ed. New York, N Y: WH Freeman; 2003. Male DK, Cooke A, Owen M, Trowsdale J, Champion B. Advanced Immunology. 3rd ed. 5t Louis, MO: Mosby; 1996. Antibody-Mediated Immune Effector Responses Structural and functional properties of antibody molecules Structural features of immunoglobulins Five major classes (M, G, A, E, and D) of immunoglobulin exist in 9 different subclasses, or isotypes (IgGI, IgG2, IgG3, IgG4, IgM, IgAI, IgA2, IgE, and IgD). The basic immunoglobulin structure is composed of 4 covalently bonded glycoprotein chains that form a monomer of approximately 150,000- 180,000 daltons (Fig 2-6).

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