By American Academy of Ophthalmology, Robert H. Rosa Jr. MD
Part four offers fabrics in components: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: scientific facets. half I makes use of a hierarchy that strikes from basic to precise to aid derive a differential analysis for a particular tissue. half II is a compilation of chosen medical points of significance to the overall ophthalmologist. Following half II are the yank Joint Committee on melanoma 2010 staging varieties for ocular and adnexal tumors.
Upon crowning glory of part four, readers might be capable to:
Describe a established method of realizing significant ocular stipulations in accordance with a hierarchical framework of topography, affliction strategy, basic prognosis and differential diagnosis
Summarize the stairs in dealing with ocular specimens for pathologic research, together with acquiring, dissecting, processing, and marking tissues
Identify these ophthalmic lesions that point out systemic sickness and are possibly lifestyles threatening
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Extra info for 2014-2015 Basic and Clinical Science Course (BCSC): Section 4: Ophthalmic Pathology and Intraocular Tumors
Around the wound and actively contract, resu lting in a volumetLic decrease in the size of the wound: The eyelid and orbit are ,compartmentalized by intertwining fascia! membranes enclosing muscular, tendinous, fatty, lacrimal, and ocular tissues that are distol'ted by scarring. Exuberant contracting di torts muscle action, producing dysfunctional scars. The triated. muscles of the orbicuJaris oculi and extraocular muscles are made of tem1inally differentiated cells that do not regenerate, but the viable cell may hypertrophy.
Rn, 'fwo techniques are used for as e mg the margms m eyehd carcinomas (basal cell a quamou cell ciircinoma, and ebaceous carcinoma): routine frozen sections . carcinom ' . . . and Mohs micrograi hie ~-gery. Moh surg~ry preserves tissue while ~bta_mmg free mar. in · 1 y rnainlai11 adequate cosmetic and functional results. Other frequent indications 110n · . . r frozen secUons are to deternune whether the surgeon has obtamed, through biopsy, r~presentative material for diagnosis. or flow cytometryand molecular genetics (eg, cancers).
In the 1990s, traditional diagnostic approaches were supplemented by the successful application of these newer techniques (see Table 4-2) to formalin- fixed, paraffin-embedded tissue, making it possible to subject a broader range of clinical material to molecular analysis. Thus, molecular genetics has already become an integral part of the workup of tumors, such as pediatric orbital tumors (rhabdomyosarcomas, CHAPTER 4: Special Procedures • 43 ,, ·oblastoma , peripheral neuroectodermal tumors [PNET]), that demonstrate charnew .