By Erna E. Kritzinger
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Additional resources for A Colour Atlas of Optic Disc Abnormalities
Invest Ophthalmol. Vis. Sci. 48, 5058-5067. 3 Homocysteine in the Pathogenesis of Chronic Glaucoma Mustafa R Kadhim1 and Colin I Clement2,3 Western Eye Hospital, London, Unit, Sydney Eye Hospital, Sydney, 3Central Clinical School, The University of Sydney, Sydney 1United Kingdom 2,3Australia 2Glaucoma 1The 1. 1 Metabolic pathway Methionine is one of four amino acids that form succinyl CoA. This sulphur containing amino acid is the source of homocysteine (Hcy). It is converted to S-adenosylmethionine (SAM), the major methyl-group donor in one–carbon metabolism.
It is important for the stability of intermolecular crosslinks in basement membranes. These data support our idea that the two populations of ONH astrocytes respond differently to elevated hydrostatic pressure with respect to changes in gene expression. Some responses may be due to intrinsically lower expression in the AA astrocyte population that is enhanced by elevated HP, while others appear to be specifically up-regulated in these cells. , 2009). The strategy here was to determine whether changes in gene expression can be correlated with changes in protein phosphorylation in ONH astrocytes subjected to elevated HP.
Ophthalmol. 83, 209218. R. (1999b). Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma. Exp. Eye Res. 68, 29-40. L. (1999). The relationship between optic disc area and open-angle glaucoma: the Baltimore Eye Survey. J. Glaucoma. 8, 347-352. A. and Vitale,S. (1997). Models of open-angle glaucoma prevalence and incidence in the United States. Invest Ophthalmol. Vis. Sci. 38, 83-91. R. (2000). Selective expression of neural cell adhesion molecule (NCAM)-180 in optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro.